The Giants and 49ers have met 41 times combined in the regular season and postseason. The Giants have 21 victories, the 49ers have 20. In those 41 games, they are separated by only five points (Giants 843, 49ers 838).
Doubtful: DB Adrian Colbert (quad)
Questionable: DB Brandon Williams (groin)
San Francisco 49ers
Out: RB Tevin Coleman (knee), DE Dee Ford (back), QB Jimmy Garoppolo (ankle), LB Dre Greenlaw (quad), TE George Kittle (knee), RB Raheem Mostert (knee)
Questionable: CB Ahkello Witherspoon (hamstring)
The Giants and 49ers have split their last four games dating back to 2014, with each team winning once at home and once on the road. They last faced each other on Monday night, Nov. 12, 2018 in Santa Clara, where Eli Manning’s three-yard touchdown pass to Sterling Shepard with 53 seconds remaining in the game capped a 75-yard drive and gave the Giants a 27-23 victory.
Last Time Out
The Giants dropped to 0-2 after a 17-13 loss in Chicago, a game in which they trailed 17-0 at halftime. It was the first time they lost despite shutting out their opponent in the second half since Nov. 21, 2004 vs. Atlanta – Eli Manning’s first start at quarterback. The Giants have allowed 43 points through two games; last year, they allowed 63 in the first two weeks.
San Francisco, meanwhile, improved to 1-1 in their quest to defend the conference crown by defeating the New York Jets, 31-13, at MetLife Stadium. The 49ers are one of three teams in the NFL (Rams and Vikings) to score on each of their opening possessions in the first two.
games, coming away with a 52-yard Robbie Gould field goal in Week 1 and an 80-yard touchdown run by Raheem Mostert on the first play from scrimmage last week against the Jets. In 2019, when they reached the Super Bowl, the 49ers scored 54 points on their opening possessions, tied with Kansas City and Oakland for the second-most in the league. Baltimore led with 64.
Week 2 was unkind to the 49ers on the injury front, as it was to the Giants, who saw Saquon Barkley suffer a season-ending knee injury and Sterling Shepard leave with turf toe. San.
Francisco lost defensive linemen Nick Bosa, the 2019 NFL Defensive Rookie of the Year, and Solomon Thomas for the year due to knee injuries. The injuries didn’t stop there. Starting quarterback Jimmy Garoppolo suffered an ankle injury and was ruled out for Sunday. Below is a look at the complete injury report:
Freeman was selected to the Pro Bowl after both the 2015 and 2016 seasons, when he totaled 2,135 rushing yards, 127 catches and 27 touchdowns. His 11 rushing touchdowns in 2015 led the NFL.
QB Nick Mullens to Start for 49ers
Nick Mullens has started eight previous games in his career, including a 2018 meeting with the Giants. He threw one touchdown and two interceptions before the Giants won on a last-minute touchdown pass from Eli Manning to Sterling Shepard.
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